Ontology highlight
ABSTRACT:
SUBMITTER: Wilson DN
PROVIDER: S-EPMC2533191 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Wilson Daniel N DN Schluenzen Frank F Harms Joerg M JM Starosta Agata L AL Connell Sean R SR Fucini Paola P
Proceedings of the National Academy of Sciences of the United States of America 20080829 36
The oxazolidinones represent the first new class of antibiotics to enter into clinical usage within the past 30 years, but their binding site and mechanism of action has not been fully characterized. We have determined the crystal structure of the oxazolidinone linezolid bound to the Deinococcus radiodurans 50S ribosomal subunit. Linezolid binds in the A site pocket at the peptidyltransferase center of the ribosome overlapping the aminoacyl moiety of an A-site bound tRNA as well as many clinical ...[more]