Ontology highlight
ABSTRACT:
SUBMITTER: Barstow B
PROVIDER: S-EPMC2533195 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Barstow Buz B Ando Nozomi N Kim Chae Un CU Gruner Sol M SM
Proceedings of the National Academy of Sciences of the United States of America 20080903 36
A protein molecule is an intricate system whose function is highly sensitive to small external perturbations. However, no examples that correlate protein function with progressive subangstrom structural perturbations have thus far been presented. To elucidate this relationship, we have investigated a fluorescent protein, citrine, as a model system under high-pressure perturbation. The protein has been compressed to produce deformations of its chromophore by applying a high-pressure cryocooling t ...[more]