Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors.
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ABSTRACT:
SUBMITTER: Paeshuyse J
PROVIDER: S-EPMC2533444 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Publications
Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors.
Paeshuyse Jan J Vliegen Inge I Coelmont Lotte L Leyssen Pieter P Tabarrini Oriana O Herdewijn Piet P Mittendorfer Harald H Easmon Johnny J Cecchetti Violetta V Bartenschlager Ralf R Puerstinger Gerhard G Neyts Johan J
Antimicrobial agents and chemotherapy 20080714 9
We report here a comparative study of the anti-hepatitis C virus (HCV) activities of selected (i) nucleoside polymerase, (ii) nonnucleoside polymerase, (iii) alpha,gamma-diketo acid polymerase, (iv) NS3 protease, and (v) helicase inhibitors, as well as (vi) cyclophilin binding molecules and (vii) alpha 2b interferon in four different HCV genotype 1b replicon systems. ...[more]
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