The KQ element, a complex genetic region conferring transferable resistance to carbapenems, aminoglycosides, and fluoroquinolones in Klebsiella pneumoniae.
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ABSTRACT:
SUBMITTER: Rice LB
PROVIDER: S-EPMC2533511 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
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The KQ element, a complex genetic region conferring transferable resistance to carbapenems, aminoglycosides, and fluoroquinolones in Klebsiella pneumoniae.
Rice Louis B LB Carias Lenore L LL Hutton Rebecca A RA Rudin Susan D SD Endimiani Andrea A Bonomo Robert A RA
Antimicrobial agents and chemotherapy 20080623 9
The bla(KPC-3) and qnrB19 determinants of transferable Klebsiella pneumoniae plasmid pLRM24 reside within a complex region consisting of a Tn1331 backbone into which a Tn4401-like element and qnrB19 mobilized by an adjacent ISEcp1 insertion sequence have been inserted. This novel element represents a coalescence of genes conferring multidrug resistance in K. pneumoniae. ...[more]
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