Ontology highlight
ABSTRACT:
SUBMITTER: Lev-Maor G
PROVIDER: S-EPMC2533698 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Lev-Maor Galit G Ram Oren O Kim Eddo E Sela Noa N Goren Amir A Levanon Erez Y EY Ast Gil G
PLoS genetics 20080926 9
Examination of the human transcriptome reveals higher levels of RNA editing than in any other organism tested to date. This is indicative of extensive double-stranded RNA (dsRNA) formation within the human transcriptome. Most of the editing sites are located in the primate-specific retrotransposed element called Alu. A large fraction of Alus are found in intronic sequences, implying extensive Alu-Alu dsRNA formation in mRNA precursors. Yet, the effect of these intronic Alus on splicing of the fl ...[more]