Ontology highlight
ABSTRACT:
SUBMITTER: Bandaria JN
PROVIDER: S-EPMC2533850 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20071208 1
The role of femtosecond-picosecond structural dynamics of proteins in enzyme-catalyzed reactions is a hotly debated topic. We report infrared photon echo measurement of the formate dehydrogenase-NAD+-azide ternary complex. In contrast to earlier studies of protein dynamics, the data show complete spectral diffusion on the femtosecond-picosecond time scale with no static heterogeneity. This result indicates that this transition-state analogue complex completely samples the distribution of structu ...[more]