Dataset Information
Modeling cellular deformations using the level set formalism.
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ABSTRACT: Background
Many cellular processes involve substantial shape changes. Traditional simulations of these cell shape changes require that grids and boundaries be moved as the cell's shape evolves. Here we demonstrate that accurate cell shape changes can be recreated using level set methods (LSM), in which the cellular shape is defined implicitly, thereby eschewing the need for updating boundaries.Results
We obtain a viscoelastic model of Dictyostelium cells using micropipette aspiration and show how this viscoelastic model can be incorporated into LSM simulations to recreate the observed protrusion of cells into the micropipette faithfully. We also demonstrate the use of our techniques by simulating the cell shape changes elicited by the chemotactic response to an external chemoattractant gradient.Conclusion
Our results provide a simple but effective means of incorporating cellular deformations into mathematical simulations of cell signaling. Such methods will be useful for simulating important cellular events such as chemotaxis and cytokinesis.
SUBMITTER: Yang L
PROVIDER: S-EPMC2535594 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Publications
Modeling cellular deformations using the level set formalism.
BMC systems biology 20080724
<h4>Background</h4>Many cellular processes involve substantial shape changes. Traditional simulations of these cell shape changes require that grids and boundaries be moved as the cell's shape evolves. Here we demonstrate that accurate cell shape changes can be recreated using level set methods (LSM), in which the cellular shape is defined implicitly, thereby eschewing the need for updating boundaries.<h4>Results</h4>We obtain a viscoelastic model of Dictyostelium cells using micropipette aspira ...[more]