Ontology highlight
ABSTRACT:
SUBMITTER: de las Fuentes L
PROVIDER: S-EPMC2536614 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20080411 8
<h4>Background</h4>Osteopontin (OPN)-transgenic mice exhibit increased carotid artery intima-media thickness (CIMT), smooth muscle cell proliferation, and atheroma formation.<h4>Methods</h4>An association of the human T-66G promoter variant with CIMT was examined in Caucasian adults grouped according to metabolic syndrome criteria: present (+MetS; n = 70) or absent (-MetS; n = 70).<h4>Results</h4>The G-allele frequency was 22%. For the entire cohort, the G group (TG and GG) was associated with s ...[more]