Ontology highlight
ABSTRACT:
SUBMITTER: Tang G
PROVIDER: S-EPMC2536619 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20070323 8
We report herein a new class of small-molecule inhibitors of antiapoptotic Bcl-2 proteins. The most potent compound, 7, binds to Bcl-2, Bcl-xL, and Mcl-1 proteins with Ki of 110, 638, and 150 nM, respectively. Compound 7 is highly effective in induction of cell death in breast cancer cells with high levels of Bcl-2, Bcl-xL, and Mcl-1 proteins and represents a promising lead compound for the design of new anticancer drugs. ...[more]