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Functional DNAzymes organized into two-dimensional arrays.

ABSTRACT: DNAzymes are catalytically active DNA molecules, which have previously been described in solution. Here, we organize these molecules into a series of two-dimensional (2D) arrays using a periodic arrangement of DNA structures based on the DNA double crossover motif. We demonstrate by means of atomic force microscopy that the DNAzymes are organized according to the design and that they retain their activity when attached in linear strings within the context of the 2D array.

SUBMITTER: Garibotti AV

PROVIDER: S-EPMC2536694 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature

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Functional DNAzymes organized into two-dimensional arrays.

Garibotti Alejandra V AV Knudsen Scott M SM Ellington Andrew D AD Seeman Nadrian C NC

Nano letters 20060701 7

DNAzymes are catalytically active DNA molecules, which have previously been described in solution. Here, we organize these molecules into a series of two-dimensional (2D) arrays using a periodic arrangement of DNA structures based on the DNA double crossover motif. We demonstrate by means of atomic force microscopy that the DNAzymes are organized according to the design and that they retain their activity when attached in linear strings within the context of the 2D array. ...[more]

PMID: 16834439

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