Optimal screening for promising genes in 2-stage designs.

ABSTRACT: Detecting genetic markers with biologically relevant effects remains a challenge due to multiple testing. Standard analysis methods focus on evidence against the null and protect primarily the type I error. On the other hand, the worthwhile alternative is specified for power calculations at the design stage. The balanced test as proposed by Moerkerke and others (2006) and Moerkerke and Goetghebeur (2006) incorporates this alternative directly in the decision criterion to achieve better power. Genetic markers are selected and ranked in order of the balance of evidence they contain against the null and the target alternative. In this paper, we build on this guiding principle to develop 2-stage designs for screening genetic markers when the cost of measurements is high. For a given marker, a

SUBMITTER: Moerkerke B 

PROVIDER: S-EPMC2536725 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature