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Receptor tyrosine kinases: mechanisms of activation and signaling.

ABSTRACT: Receptor tyrosine kinases (RTKs) are essential components of signal transduction pathways that mediate cell-to-cell communication. These single-pass transmembrane receptors, which bind polypeptide ligands - mainly growth factors - play key roles in processes such as cellular growth, differentiation, metabolism and motility. Recent progress has been achieved towards an understanding of the precise (and varied) mechanisms by which RTKs are activated by ligand binding and by which signals are propagated from the activated receptors to downstream targets in the cell.

SUBMITTER: Hubbard SR

PROVIDER: S-EPMC2536775 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature

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Receptor tyrosine kinases: mechanisms of activation and signaling.

Hubbard Stevan R SR Miller W Todd WT

Current opinion in cell biology 20070216 2

Receptor tyrosine kinases (RTKs) are essential components of signal transduction pathways that mediate cell-to-cell communication. These single-pass transmembrane receptors, which bind polypeptide ligands - mainly growth factors - play key roles in processes such as cellular growth, differentiation, metabolism and motility. Recent progress has been achieved towards an understanding of the precise (and varied) mechanisms by which RTKs are activated by ligand binding and by which signals are propa ...[more]

PMID: 17306972

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