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High oxygen prevents fetal lethality due to lack of catecholamines.

ABSTRACT: The catecholamine norepinephrine is required for fetal survival, but its essential function is unknown. When catecholamine-deficient [tyrosine hydroxylase (Th) null] mouse fetuses die at embryonic day (E)13.5-14.5, they resemble wild-type (wt) fetuses exposed to hypoxia. They exhibit bradycardia (28% reduction in heart rate), thin ventricular myocardium (20% reduction in tissue), epicardial detachment, and death with vascular congestion, hemorrhage, and edema. At E12.5, before the appearance of morphological deficits, catecholamine-deficient fetuses are preferentially killed by experimentally induced hypoxia and have lower tissue Po(2) levels than wt siblings. By microarray analysis (http://www.ncbi.nlm.nih.gov/geo; accession no. GSE10341), hypoxia-inducible factor-1 target genes are induced to a greater extent in null fetuses than in wt siblings, supporting the notion that mutants experience lower oxygen tension or have an enhanced response to hypoxia. Hypoxia induces a 13-fold increase in plasma norepinephrine levels, which would be expected to increase heart rate, thereby improving oxygen delivery in wt mice. Surprisingly, increasing maternal oxygen (inspired O(2) 33 or 63%) prevents the effects of catecholamine deficiency, restoring heart rate, myocardial tissue, and survival of Th null fetuses to wt levels. We suggest that norepinephrine mediates fetal survival by maintaining oxygen homeostasis.

SUBMITTER: Ream MA

PROVIDER: S-EPMC2536863 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature

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High oxygen prevents fetal lethality due to lack of catecholamines.

Ream Margie A MA Chandra Rashmi R Peavey Mary M Ray Alisa M AM Roffler-Tarlov Suzanne S Kim Hyung-Gun HG Wetsel William C WC Rockman Howard A HA Chikaraishi Dona M DM

American journal of physiology. Regulatory, integrative and comparative physiology 20080716 3

The catecholamine norepinephrine is required for fetal survival, but its essential function is unknown. When catecholamine-deficient [tyrosine hydroxylase (Th) null] mouse fetuses die at embryonic day (E)13.5-14.5, they resemble wild-type (wt) fetuses exposed to hypoxia. They exhibit bradycardia (28% reduction in heart rate), thin ventricular myocardium (20% reduction in tissue), epicardial detachment, and death with vascular congestion, hemorrhage, and edema. At E12.5, before the appearance of ...[more]

PMID: 18635452

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High oxygen prevents fetal lethality due to lack of catecholamines.

Publications

High oxygen prevents fetal lethality due to lack of catecholamines.

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