Molecular recognition of nitrated fatty acids by PPAR gamma.
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ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC2538624 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Publications
Molecular recognition of nitrated fatty acids by PPAR gamma.
Li Yong Y Zhang Jifeng J Schopfer Francisco J FJ Martynowski Dariusz D Garcia-Barrio Minerva T MT Kovach Amanda A Suino-Powell Kelly K Baker Paul R S PR Freeman Bruce A BA Chen Y Eugene YE Xu H Eric HE
Nature structural & molecular biology 20080706 8
Peroxisome proliferator activated receptor-gamma (PPAR gamma) regulates metabolic homeostasis and adipocyte differentiation, and it is activated by oxidized and nitrated fatty acids. Here we report the crystal structure of the PPAR gamma ligand binding domain bound to nitrated linoleic acid, a potent endogenous ligand of PPAR gamma. Structural and functional studies of receptor-ligand interactions reveal the molecular basis of PPAR gamma discrimination of various naturally occurring fatty acid d ...[more]
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