Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC2538893 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Zhang Xiaoqun X Andren Per E PE Greengard Paul P Svenningsson Per P
Proceedings of the National Academy of Sciences of the United States of America 20080206 6
Parkinson's disease (PD) is characterized by a progressive degeneration of substantia nigra dopaminergic neurons projecting to the striatum. Restoration of dopamine transmission by L-DOPA relieves symptoms of PD but causes prominent side effects. There is a strong serotonin innervation of the striatum by serotonergic neurons that remains relatively preserved in PD. The study of this innervation has been largely neglected. Here, we demonstrate that chronic L-DOPA administration to 6-OHDA-lesioned ...[more]