Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock.

ABSTRACT:

Rationale

Interventional clinical trials involving children with septic shock would benefit from an efficient preenrollment stratification strategy.

Objectives

To test the predictive value of interleukin (IL)-8 for 28-day mortality in pediatric septic shock.

Methods

A training data set (n = 40) identified a serum IL-8 of greater than 220 pg/ml as having a 75% sensitivity and specificity for predicting 28-day mortality. This cutoff was then subjected to a series of validation steps.

Measurements and main results

Subjects were drawn from two large, independent pediatric septic shock databases. Prospective application of the IL-8 cutoff to validation data set 1 (n = 139) demonstrated 78% sensitivity and 64% specificity for 28-day mortality. A serum IL-8 level of 2

SUBMITTER: Wong HR 

PROVIDER: S-EPMC2542425 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature