Traffic-related particles are associated with elevated homocysteine: the VA normative aging study.

ABSTRACT:

Rationale

Recent epidemiologic studies have shown that homocysteine, a sulfur-containing amino acid formed during the metabolism of methionine, is a risk factor for atherosclerosis, myocardial infarction, stroke, and thrombosis. Particulate air pollution has been related to cardiovascular death and hospital admission, but the underlying mechanisms are not fully elucidated.

Objectives

We examined the associations between ambient particulate air pollution and plasma concentrations of homocysteine among 960 community-residing older men (mean age, 73.6 +/- 6.9 yr).

Methods

Total homocysteine in plasma, measured using high-performance liquid chromatography with fluorescence detection, was regressed on each ambient particulate pollutant (black carbon, organic carbon, sulfat

SUBMITTER: Park SK 

PROVIDER: S-EPMC2542426 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature