Unknown

Dataset Information

0

Changes in arterial oxygenation and self-reported oxygen use after lung volume reduction surgery.


ABSTRACT:

Rationale

Lung volume reduction surgery (LVRS) is inconsistently reported to improve arterial oxygenation in patients with chronic obstructive pulmonary disease.

Objectives

We studied the effects of surgery on oxygenation in a large cohort and identified predictors of postoperative oxygenation improvement.

Methods

We evaluated oxygenation in 1,078 subjects with chronic obstructive pulmonary disease enrolled in the National Emphysema Treatment Trial after LVRS compared with medical control subjects, including arterial blood gases, use of supplemental oxygen during treadmill walking, and self-reported use of oxygen during rest, exertion, and sleep.

Measurements and main results

Pa(O(2)) breathing room air was equal in medical and surgical subjects at baseline (64.8 vs. 65.0 mm Hg, P = not significant), but lower in medical subjects at 6 months (63.6 vs. 70.0 mm Hg, P < 0.001), 12 months (63.9 vs. 68.7 mm Hg, P < 0.001), and 24 months (62.4 vs. 68.0 mm Hg, P < 0.001). Fewer medical subjects required oxygen for treadmill walking at baseline compared with surgical subjects (46 vs. 53%, P = 0.02). However, more medical subjects required oxygen for this activity at 6 months (49 vs. 33%, P < 0.001), 12 months (50 vs. 36%, P < 0.001), and 24 months (52 vs. 42%, P = 0.02). Self-reported oxygen use was greater in medical than in surgical subjects at 6, 12, and 24 months. Multivariate modeling of preoperative characteristics showed baseline oxygenation status was the best predictor of postoperative oxygenation.

Conclusions

LVRS increases Pa(O(2)), and decreases treadmill and self-reported use of oxygen for up to 24 months post-procedure. Clinical trial registered with www.clinicaltrials.gov (NCT 00000606).

SUBMITTER: Snyder ML 

PROVIDER: S-EPMC2542439 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Changes in arterial oxygenation and self-reported oxygen use after lung volume reduction surgery.

Snyder Margaret L ML   Goss Christopher H CH   Neradilek Blazej B   Polissar Nayak L NL   Mosenifar Zab Z   Wise Robert A RA   Fishman Alfred P AP   Benditt Joshua O JO  

American journal of respiratory and critical care medicine 20080605 4


<h4>Rationale</h4>Lung volume reduction surgery (LVRS) is inconsistently reported to improve arterial oxygenation in patients with chronic obstructive pulmonary disease.<h4>Objectives</h4>We studied the effects of surgery on oxygenation in a large cohort and identified predictors of postoperative oxygenation improvement.<h4>Methods</h4>We evaluated oxygenation in 1,078 subjects with chronic obstructive pulmonary disease enrolled in the National Emphysema Treatment Trial after LVRS compared with  ...[more]

Similar Datasets

| S-EPMC6461146 | biostudies-literature
| S-EPMC1746757 | biostudies-literature
| S-EPMC2970864 | biostudies-literature
| S-EPMC2048957 | biostudies-literature
| S-EPMC7589281 | biostudies-literature
| S-EPMC1994220 | biostudies-literature
| S-EPMC6373585 | biostudies-literature
| S-EPMC10133584 | biostudies-literature
| S-EPMC10323600 | biostudies-literature
| S-EPMC4251617 | biostudies-other