Ontology highlight
ABSTRACT:
SUBMITTER: Moore S
PROVIDER: S-EPMC2543117 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Moore Susanna S Jaeschke Holger H Kleinau Gunnar G Neumann Susanne S Costanzi Stefano S Jiang Jian-kang JK Childress John J Raaka Bruce M BM Colson Anny A Paschke Ralf R Krause Gerd G Thomas Craig J CJ Gershengorn Marvin C MC
Journal of medicinal chemistry 20060601 13
The substituted thieno[2,3-d]pyrimidine 3 (Org 41841), a partial agonist for the luteinizing hormone/choriogonadotropin receptor (LHCGR) and the closely related thyroid-stimulating hormone receptor (TSHR), was fundamentally altered, and the resulting analogues were analyzed for their potencies, efficacies, and specificities at LHCGR and TSHR. Chemical modification of the parent compound combined with prior mutagenesis of TSHR provided compelling experimental evidence in support of computational ...[more]