Ontology highlight
ABSTRACT:
SUBMITTER: Roca M
PROVIDER: S-EPMC2544547 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Roca Maite M Messer Benjamin B Hilvert Donald D Warshel Arieh A
Proceedings of the National Academy of Sciences of the United States of America 20080908 37
Elucidating the relationship between the folding landscape of enzymes and their catalytic power has been one of the challenges of modern enzymology. The present work explores this issue by using a simplified folding model to generate the free-energy landscape of an enzyme and then to evaluate the activation barriers for the chemical step in different regions of the landscape. This approach is used to investigate the recent finding that an engineered monomeric chorismate mutase exhibits catalytic ...[more]