Cancer genes hypermethylated in human embryonic stem cells.
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ABSTRACT:
SUBMITTER: Calvanese V
PROVIDER: S-EPMC2546447 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Publications
Cancer genes hypermethylated in human embryonic stem cells.
Calvanese Vincenzo V Horrillo Angelica A Hmadcha Abdelkrim A Suarez-Alvarez Beatriz B Fernandez Agustín F AF Lara Ester E Casado Sara S Menendez Pablo P Bueno Clara C Garcia-Castro Javier J Rubio Ruth R Lapunzina Pablo P Alaminos Miguel M Borghese Lodovica L Terstegge Stefanie S Harrison Neil J NJ Moore Harry D HD Brüstle Oliver O Lopez-Larrea Carlos C Andrews Peter W PW Soria Bernat B Esteller Manel M Fraga Mario F MF
PloS one 20080929 9
Developmental genes are silenced in embryonic stem cells by a bivalent histone-based chromatin mark. It has been proposed that this mark also confers a predisposition to aberrant DNA promoter hypermethylation of tumor suppressor genes (TSGs) in cancer. We report here that silencing of a significant proportion of these TSGs in human embryonic and adult stem cells is associated with promoter DNA hypermethylation. Our results indicate a role for DNA methylation in the control of gene expression in ...[more]
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