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Total synthesis of (-)-mucocin.


ABSTRACT: [reaction: see text] An enantioselective total synthesis of (-)-mucocin has been completed. A combination of asymmetric glycolate aldol additions and ring closing metathesis reactions were exploited to construct the C18-C34 and C7-C17 fragments. A selective cross-metathesis reaction was employed as the key step to couple two complex fragments.

SUBMITTER: Crimmins MT 

PROVIDER: S-EPMC2546581 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature

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Total synthesis of (-)-mucocin.

Crimmins Michael T MT   Zhang Yan Y   Diaz Frank A FA  

Organic letters 20060501 11


[reaction: see text] An enantioselective total synthesis of (-)-mucocin has been completed. A combination of asymmetric glycolate aldol additions and ring closing metathesis reactions were exploited to construct the C18-C34 and C7-C17 fragments. A selective cross-metathesis reaction was employed as the key step to couple two complex fragments. ...[more]

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