Deficiency of Mbd2 attenuates Wnt signaling.
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ABSTRACT:
SUBMITTER: Phesse TJ
PROVIDER: S-EPMC2547016 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Publications
Deficiency of Mbd2 attenuates Wnt signaling.
Phesse Toby J TJ Parry Lee L Reed Karen R KR Ewan Kenneth B KB Dale Trevor C TC Sansom Owen J OJ Clarke Alan R AR
Molecular and cellular biology 20080721 19
We have previously shown that deficiency of the methyl binding domain protein Mbd2 dramatically reduces adenoma burden on an Apc(Min/+) background. To investigate the mechanism underlying this phenomenon, we have determined the effect of Mbd2 deficiency upon the phenotypes imposed by the conditional deletion of Apc in the small intestine. Microarray analysis demonstrated a partial suppression of the Wnt pathway in the absence of Mbd2. Mbd2 deficiency also influenced one immediate cellular conseq ...[more]
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