Upregulation of Runx2 and Osterix during in vitro chondrogenesis of human adipose-derived stromal cells.
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ABSTRACT:
SUBMITTER: Rich JT
PROVIDER: S-EPMC2548292 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
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Upregulation of Runx2 and Osterix during in vitro chondrogenesis of human adipose-derived stromal cells.
Rich Jason T JT Rosová Ivana I Nolta Jan A JA Myckatyn Terence M TM Sandell Linda J LJ McAlinden Audrey A
Biochemical and biophysical research communications 20080513 1
The aim of this study was to create a gene expression profile to better define the phenotype of human adipose-derived stromal cells (HADSCs) during in vitro chondrogenesis, osteogenesis and adipogenesis. A novel aspect of this work was the analysis of the same subset of genes during HADSC differentiation into all three lineages. Chondrogenic induction resulted in increased mRNA expression of Sox transcription factors, COL2A1,COL10A1, Runx2, and Osterix. This is the first report demonstrating sig ...[more]
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