Ontology highlight
ABSTRACT:
SUBMITTER: Gaits F
PROVIDER: S-EPMC25496 | biostudies-literature | 1999 Aug
REPOSITORIES: biostudies-literature
Molecular biology of the cell 19990801 8
The gene ptc4+ encodes one of four type 2C protein phosphatases (PP2C) in the fission yeast Schizosaccharomyces pombe. Deletion of ptc4+ is not lethal; however, Deltaptc4 cells grow slowly in defined minimal medium and undergo premature growth arrest in response to nitrogen starvation. Interestingly, Deltaptc4 cells are unable to fuse vacuoles in response to hypotonic stress or nutrient starvation. Conversely, Ptc4 overexpression appears to induce vacuole fusion. These findings reveal a hitherto ...[more]