CD47: a new target in cardiovascular therapy.
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ABSTRACT:
SUBMITTER: Isenberg JS
PROVIDER: S-EPMC2553319 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Publications
CD47: a new target in cardiovascular therapy.
Isenberg Jeff S JS Roberts David D DD Frazier William A WA
Arteriosclerosis, thrombosis, and vascular biology 20080110 4
CD47, originally named integrin-associated protein, is a receptor for thrombospondin-1. A number of important roles for CD47 have been defined in regulating the migration, proliferation, and survival of vascular cells, and in regulation of innate and adaptive immunity. The recent discovery that thrombospondin-1 acts via CD47 to inhibit nitric oxide signaling throughout the vascular system has given new importance and perhaps a unifying mechanism of action to these enigmatic proteins. Here we tra ...[more]
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