Ontology highlight
ABSTRACT:
SUBMITTER: van den Born E
PROVIDER: S-EPMC2553587 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
van den Born Erwin E Omelchenko Marina V MV Bekkelund Anders A Leihne Vibeke V Koonin Eugene V EV Dolja Valerian V VV Falnes Pål Ø PØ
Nucleic acids research 20080821 17
Bacterial and mammalian AlkB proteins are iron(II)- and 2-oxoglutarate-dependent dioxygenases that reverse methylation damage, such as 1-methyladenine and 3-methylcytosine, in RNA and DNA. An AlkB-domain is encoded by the genome of numerous single-stranded, plant-infecting RNA viruses, the majority of which belong to the Flexiviridae family. Our phylogenetic analysis of AlkB sequences suggests that a single plant virus might have acquired AlkB relatively recently, followed by horizontal dissemin ...[more]