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Protease-modulated cellular uptake of quantum dots.

ABSTRACT: Quantum dots (QDs) are often cell-impermeable and require transporters to facilitate crossing over cell membranes. Here we present a simple and versatile method that utilizes enzymes, matrix metalloprotease 2 (MMP-2) and MMP-7, to modulate the cellular uptake of QDs. QD-peptide conjugates could be efficiently taken up into cells after the MMP treatment. This enzyme-modulated cellular uptake of QDs may be applied to other nanoparticles for biological imaging and selective drug delivery into tumor cells.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC2553895 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature

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Protease-modulated cellular uptake of quantum dots.

Zhang Yan Y   So Min Kyung MK   Rao Jianghong J  

Nano letters 20060901 9

Quantum dots (QDs) are often cell-impermeable and require transporters to facilitate crossing over cell membranes. Here we present a simple and versatile method that utilizes enzymes, matrix metalloprotease 2 (MMP-2) and MMP-7, to modulate the cellular uptake of QDs. QD-peptide conjugates could be efficiently taken up into cells after the MMP treatment. This enzyme-modulated cellular uptake of QDs may be applied to other nanoparticles for biological imaging and selective drug delivery into tumor  ...[more]

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