Mechanisms of transmurally varying myocyte electromechanics in an integrated computational model.
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ABSTRACT:
SUBMITTER: Campbell SG
PROVIDER: S-EPMC2556206 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
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Mechanisms of transmurally varying myocyte electromechanics in an integrated computational model.
Campbell Stuart G SG Flaim Sarah N SN Leem Chae H CH McCulloch Andrew D AD
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 20080901 1879
The mechanical properties of myocardium vary across the transmural aspect of the left ventricular wall. Some of these functional heterogeneities may be related to differences in excitation-contraction coupling characteristics that have been observed in cells isolated from the epicardial, mid-myocardial and endocardial regions of the left ventricle of many species, including canine. Integrative models of coupled myocyte electromechanics are reviewed and used here to investigate sources of heterog ...[more]
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