Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1.
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ABSTRACT:
SUBMITTER: Kim H
PROVIDER: S-EPMC2556249 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Publications
Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1.
Kim Hyunsoo H Deng Liu L Xiong Xin X Hunter William D WD Long Melissa C MC Pirrung Michael C MC
Journal of medicinal chemistry 20070627 15
This study was undertaken to identify cellular proteins that bind an orally active natural product insulin mimic. Phage display cloning was used with a biotinylated derivative of this molecule as bait. Among the proteins identified was glyceraldehyde 3-phosphate dehydrogenase (GAPDH), which has recently been shown to affect insulin receptor signaling. Binding data support a role for human GAPDH as another target of the insulin mimic, which could explain its action as a selective insulin receptor ...[more]
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