Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties.
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ABSTRACT:
SUBMITTER: Rele SM
PROVIDER: S-EPMC2556565 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Publications
Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties.
Rele Shyam M SM Cui Wanxing W Wang Lianchun L Hou Sijian S Barr-Zarse Ginger G Tatton Daniel D Gnanou Yves Y Esko Jeffrey D JD Chaikof Elliot L EL
Journal of the American Chemical Society 20050701 29
A new class of high molecular weight polysulfated PEO dendrimer-like glycopolymer has been synthesized by a combination of arm-first and core-first methodologies followed by trichloroacetimidate glycosidation as a facile bioconjugation strategy. An L-selectin antagonist was identified that exhibits 103-fold greater activity than other multivalent sLex glycopolymers and 20-50 times greater potency than other linear heparinoids. A significant reduction in inflammatory cell recruitment was observed ...[more]
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