Ontology highlight
ABSTRACT:
SUBMITTER: Hippen KL
PROVIDER: S-EPMC2556620 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Hippen Keli L KL Harker-Murray Paul P Porter Stephen B SB Merkel Sarah C SC Londer Aryel A Taylor Dawn K DK Bina Megan M Panoskaltsis-Mortari Angela A Rubinstein Pablo P Van Rooijen Nico N Golovina Tatiana N TN Suhoski Megan M MM Miller Jeffrey S JS Wagner John E JE June Carl H CH Riley James L JL Blazar Bruce R BR
Blood 20080721 7
Previously, we showed that human umbilical cord blood (UCB) regulatory T cells (Tregs) could be expanded approximately 100-fold using anti-CD3/28 monoclonal antibody (mAb)-coated beads to provide T-cell receptor and costimulatory signals. Because Treg numbers from a single UCB unit are limited, we explored the use of cell-based artificial antigen-presenting cells (aAPCs) preloaded with anti-CD3/28 mAbs to achieve higher levels of Treg expansion. Compared with beads, aAPCs had similar expansion p ...[more]