Ontology highlight
ABSTRACT:
SUBMITTER: Zabel BA
PROVIDER: S-EPMC2556791 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20080915 10
Mast cells contribute importantly to both protective and pathological IgE-dependent immune responses. We show that the mast cell-expressed orphan serpentine receptor mCCRL2 is not required for expression of IgE-mediated mast cell-dependent passive cutaneous anaphylaxis but can enhance the tissue swelling and leukocyte infiltrates associated with such reactions in mice. We further identify chemerin as a natural nonsignaling protein ligand for both human and mouse CCRL2. In contrast to other "sile ...[more]