Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC2556899 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Liu Yang Y Collar Catharine J CJ Kumar Arvind A Stephens Chad E CE Boykin David W DW Wilson W David WD
The journal of physical chemistry. B 20080822 37
Given the increasing significance of diamidines as DNA-targeted therapeutics and biotechnology reagents, it is important to establish the variations in thermodynamic quantities that characterize the interactions of closely related compounds to different sequence AT binding sites. In this study, an array of methods including biosensor-surface plasmon resonance (SPR), isothermal titration microcalorimetry (ITC), circular dichroism (CD), thermal melting (Tm) and molecular modeling have been used to ...[more]