Ontology highlight
ABSTRACT:
SUBMITTER: O'Connell CB
PROVIDER: S-EPMC2557037 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
O'Connell Christopher B CB Loncarek Jadranka J Hergert Polla P Kourtidis Antonis A Conklin Douglas S DS Khodjakov Alexey A
The Journal of cell biology 20080929 1
The accuracy of chromosome segregation is enhanced by the spindle assembly checkpoint (SAC). The SAC is thought to monitor two distinct events: attachment of kinetochores to microtubules and the stretch of the centromere between the sister kinetochores that arises only when the chromosome becomes properly bioriented. We examined human cells undergoing mitosis with unreplicated genomes (MUG). Kinetochores in these cells are not paired, which implies that the centromere cannot be stretched; howeve ...[more]