Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC2557040 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Wang Xuan X Pasolli H Amalia HA Williams Trevor T Fuchs Elaine E
The Journal of cell biology 20080929 1
The mechanisms by which mammalian epidermal stem cells cease to proliferate and embark upon terminal differentiation are still poorly understood. By conditionally ablating two highly expressed transcription factors, AP-2alpha and AP-2gamma, we unmasked functional redundancies and discovered an essential role for AP-2s in the process. In vivo and in vitro, AP-2 deficiency is accompanied by surprisingly minimal changes in basal gene expression but severely perturbed terminal differentiation and su ...[more]