Ontology highlight
ABSTRACT:
SUBMITTER: Fry RC
PROVIDER: S-EPMC2559901 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Fry Rebecca C RC Svensson J Peter JP Valiathan Chandni C Wang Emma E Hogan Brad J BJ Bhattacharya Sanchita S Bugni James M JM Whittaker Charles A CA Samson Leona D LD
Genes & development 20080919 19
Human lymphoblastoid cells derived from different healthy individuals display considerable variation in their transcription profiles. Here we show that such variation in gene expression underlies interindividual susceptibility to DNA damaging agents. The results demonstrate the massive differences in sensitivity across a diverse cell line panel exposed to an alkylating agent. Computational models identified 48 genes with basal expression that predicts susceptibility with 94% accuracy. Modulating ...[more]