Comprehensive behavioral phenotyping of calpastatin-knockout mice.
Ontology highlight
ABSTRACT:
SUBMITTER: Nakajima R
PROVIDER: S-EPMC2561015 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Publications
Comprehensive behavioral phenotyping of calpastatin-knockout mice.
Nakajima Ryuichi R Takao Keizo K Huang Shu-Ming SM Takano Jiro J Iwata Nobuhisa N Miyakawa Tsuyoshi T Saido Takaomi C TC
Molecular brain 20080915
<h4>Background</h4>Calpastatin is an endogenous inhibitor of calpain, intracellular calcium-activated protease. It has been suggested to be involved in molecular mechanisms of long-term plasticity and excitotoxic pathways. However, functions of calpastatin in vivo are still largely unknown. To examine the physiological roles of calpastatin, we subjected calpastatin-knockout mice to a comprehensive behavioral test battery.<h4>Results</h4>Calpastatin-knockout mice showed decreased locomotor activi ...[more]
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