Ontology highlight
ABSTRACT:
SUBMITTER: Whitford PC
PROVIDER: S-EPMC2561047 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Whitford Paul C PC Miyashita Osamu O Levy Yaakov Y Onuchic José N JN
Journal of molecular biology 20061205 5
Conformational heterogeneity in proteins is known to often be the key to their function. We present a coarse grained model to explore the interplay between protein structure, folding and function which is applicable to allosteric or non-allosteric proteins. We employ the model to study the detailed mechanism of the reversible conformational transition of Adenylate Kinase (AKE) between the open to the closed conformation, a reaction that is crucial to the protein's catalytic function. We directly ...[more]