Ontology highlight
ABSTRACT:
SUBMITTER: Isken A
PROVIDER: S-EPMC2561276 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Isken Andrea A Golczak Marcin M Oberhauser Vitus V Hunzelmann Silke S Driever Wolfgang W Imanishi Yoshikazu Y Palczewski Krzysztof K von Lintig Johannes J
Cell metabolism 20080301 3
The cellular uptake of vitamin A from its RBP4-bound circulating form (holo-RBP4) is a homeostatic process that evidently depends on the multidomain membrane protein STRA6. In humans, mutations in STRA6 are associated with Matthew-Wood syndrome, manifested by multisystem developmental malformations. Here we addressed the metabolic basis of this inherited disease. STRA6-dependent transfer of retinol from RBP4 into cultured NIH 3T3 fibroblasts was enhanced by lecithin:retinol acyltransferase (LRAT ...[more]