Ontology highlight
ABSTRACT:
SUBMITTER: Olivier NB
PROVIDER: S-EPMC2562079 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Olivier Nelson B NB Imperiali Barbara B
The Journal of biological chemistry 20080730 41
The carbohydrate 2, 4-diacetamido-2, 4, 6-trideoxy-alpha-D-glucopyranose (BacAc(2)) is found in a variety of eubacterial pathogens. In Campylobacter jejuni, PglD acetylates the C4 amino group on UDP-2-acetamido-4-amino-2, 4, 6-trideoxy-alpha-D-glucopyranose (UDP-4-amino-sugar) to form UDP-BacAc(2). Sequence analysis predicts PglD to be a member of the left-handed beta helix family of enzymes. However, poor sequence homology between PglD and left-handed beta helix enzymes with existing structural ...[more]