Biglycan overexpression on tooth enamel formation in transgenic mice.
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ABSTRACT:
SUBMITTER: Wen X
PROVIDER: S-EPMC2562349 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Publications
Biglycan overexpression on tooth enamel formation in transgenic mice.
Wen Xin X Zou Yanming Y Luo Wen W Goldberg Michel M Moats Rex R Conti Peter S PS Snead Malcolm L ML Paine Michael L ML
Anatomical record (Hoboken, N.J. : 2007) 20081001 10
Previously, it was shown that the volume of forming enamel of molar teeth in biglycan-null mice was greater than that in genetically matched wild-type mice. This phenotypic change appeared to result from an increase in amelogenin expression, implying that biglycan directly influences amelogenin synthesis. To determine whether biglycan overexpression resulted in decreased amelogenin expression, we engineered transgenic mice to overexpress biglycan in the enamel organ epithelium. Biglycan overexpr ...[more]
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