Ontology highlight
ABSTRACT:
SUBMITTER: Lin SH
PROVIDER: S-EPMC2562662 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Lin S-H SH Cheng C-J CJ Lee Y-C YC Ye X X Tsai W-W WW Kim J J Pasqualini R R Arap W W Navone N M NM Tu S-M SM Hu M M Yu-Lee L-Y LY Logothetis C J CJ
Oncogene 20080519 39
ErbB3 is a transmembrane growth factor receptor that has been implicated in the pathogenesis of human cancer. After finding that a truncated form of ErbB3 was present and upregulated in metastatic prostate cancer cells in lymph nodes and bone, we explored the pathophysiological functions of this unusual form of ErbB3 in the context of mouse calvaria as well as osteoblasts in vitro and the femur microenvironment in vivo. Here we demonstrate that prostate cancer cells expressed an alternatively sp ...[more]