Cocaine-induced decision-making deficits are mediated by miscoding in basolateral amygdala.
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ABSTRACT:
SUBMITTER: Stalnaker TA
PROVIDER: S-EPMC2562677 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Publications
Cocaine-induced decision-making deficits are mediated by miscoding in basolateral amygdala.
Stalnaker Thomas A TA Roesch Matthew R MR Franz Theresa M TM Calu Donna J DJ Singh Teghpal T Schoenbaum Geoffrey G
Nature neuroscience 20070701 8
Addicts and drug-experienced animals have decision-making deficits in reversal-learning tasks and more complex 'gambling' variants. Here we show evidence that these deficits are mediated by persistent encoding of outdated associative information in the basolateral amygdala. Cue-selective neurons in the basolateral amygdala, recorded in cocaine-treated rats, failed to change cue preference during reversal learning. Further, the presence of these neurons was critical to the expression of the rever ...[more]
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