Ontology highlight
ABSTRACT:
SUBMITTER: Mac Donald CL
PROVIDER: S-EPMC2562788 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Mac Donald Christine L CL Dikranian Krikor K Bayly Philip P Holtzman David D Brody David D
The Journal of neuroscience : the official journal of the Society for Neuroscience 20071001 44
Traumatic axonal injury (TAI) may contribute greatly to neurological impairments after traumatic brain injury, but it is difficult to assess with conventional imaging. We quantitatively compared diffusion tensor imaging (DTI) signal abnormalities with histological and electron microscopic characteristics of pericontusional TAI in a mouse model. Two DTI parameters, relative anisotropy and axial diffusivity, were significantly reduced 6 h to 4 d after trauma, corresponding to relatively isolated a ...[more]