Ontology highlight
ABSTRACT:
SUBMITTER: Kyriakou T
PROVIDER: S-EPMC2564110 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Kyriakou Theodosios T Collins Laura J LJ Spencer-Jones Nicola J NJ Malcolm Claire C Wang Xiaoling X Snieder Harold H Swaminathan Ramasamyiyer R Burling Keith A KA Hart Deborah J DJ Spector Tim D TD O'Dell Sandra D SD
Journal of human genetics 20080604 8
Adiponectin is an insulin sensitiser in muscle and liver, and low serum levels characterise obesity and insulin resistance. Eight tagging single nucleotide polymorphisms (tSNPs) in the ADIPOQ gene and promoter were selected, and association with serum adiponectin was tested, in two independent samples of Caucasian women: the Chingford Study (n = 808, mean age 62.8 +/- 5.9 years) and Twins UK (n = 2,718, mean age 47.4 +/- 12.6 years). In the Chingford cohort, -11391 G/A, -10066 G/A (rs182052), -7 ...[more]