Ontology highlight
ABSTRACT:
SUBMITTER: Thye T
PROVIDER: S-EPMC2564561 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Thye T T Browne E N EN Chinbuah M A MA Gyapong J J Osei I I Owusu-Dabo E E Niemann S S Rüsch-Gerdes S S Horstmann R D RD Meyer C G CG
Journal of medical genetics 20060701 7
<h4>Background</h4>After a recent report on the role of the Ipr1 gene in mediating innate immunity in a mouse model of Mycobacterium tuberculosis infection, the human Ipr1 homologue, Sp110, was considered a promising candidate for an association study in human tuberculosis.<h4>Methods</h4>In a sample of >1000 sputum positive, HIV negative West African patients with pulmonary tuberculosis and >1000 exposed, apparently healthy controls, we have genotyped 21 Sp110 gene variants that were either ava ...[more]