Ontology highlight
ABSTRACT:
SUBMITTER: Girnun GD
PROVIDER: S-EPMC2564847 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Girnun Geoffrey D GD Naseri Elnaz E Vafai Scott B SB Qu Lishu L Szwaya Jeffrey D JD Bronson Roderick R Alberta John A JA Spiegelman Bruce M BM
Cancer cell 20070501 5
PPARgamma is a member of the nuclear receptor family for which agonist ligands have antigrowth effects. However, clinical studies using PPARgamma ligands as a monotherapy failed to show a beneficial effect. Here we have studied the effects of PPARgamma activation with chemotherapeutic agents in current use for specific cancers. We observed a striking synergy between rosiglitazone and platinum-based drugs in several different cancers both in vitro and using transplantable and chemically induced " ...[more]