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The LDL receptor-related protein can form homo-dimers in neuronal cells.

ABSTRACT: The ability of the low density lipoprotein receptor-related protein (LRP) to form homo-dimers was studied in mouse neuroblastoma and human neuroglioma cells as well as in primary cortical cultures from adult mouse brain. Homo-dimerization of LRP light chain (LC) was shown by several methods including co-immunoprecipitation, fluorescence lifetime imaging microscopy, and bimolecular fluorescence complementation assay. The requirement of intact NPXY motifs of LRP LC for homo-dimerization was ruled out by co-immunoprecipitation assay.

SUBMITTER: Makarova A

PROVIDER: S-EPMC2565777 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature

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The LDL receptor-related protein can form homo-dimers in neuronal cells.

Makarova Alexandra A Bercury Kathryn K KK Adams Kenneth W KW Joyner Daniel D Deng Meihua M Spoelgen Robert R Koker Mirjam M Strickland Dudley K DK Hyman Bradley T BT

Neuroscience letters 20080628 2

The ability of the low density lipoprotein receptor-related protein (LRP) to form homo-dimers was studied in mouse neuroblastoma and human neuroglioma cells as well as in primary cortical cultures from adult mouse brain. Homo-dimerization of LRP light chain (LC) was shown by several methods including co-immunoprecipitation, fluorescence lifetime imaging microscopy, and bimolecular fluorescence complementation assay. The requirement of intact NPXY motifs of LRP LC for homo-dimerization was ruled ...[more]

PMID: 18602448

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