Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics.
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ABSTRACT:
SUBMITTER: Kim JS
PROVIDER: S-EPMC2565991 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
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Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics.
Kim Joo-Sung JS Li Jiaqi J Barnes If H A IH Baltzegar David A DA Pajaniappan Mohanasundari M Cullen Thomas W TW Trent M Stephen MS Burns Christopher M CM Thompson Stuart A SA
Journal of bacteriology 20080808 19
Mutation of the cj1461 predicted methyltransferase gene reduced the motility of Campylobacter jejuni 81-176. Electron microscopy revealed that the mutant strain had flagella but with aberrant structure. The Deltacj1461 mutant was sevenfold more adherent to but 50-fold less invasive of INT-407 human epithelial cells than the wild type. ...[more]
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